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Curriculum Vitae　 　　Publications　　　Conference

Research

Publications

1. Hour, T. C., Lee, C. C. and Lin, J. K. (1995) A new mutagenicity assay method for frameshift mutagens based on deleting or inserting a guanosine nucleoside in the b-lactamase gene. Mutagenesis 10, 433-438 (NSC-83-0421-B002-240-Z) (SCI, CI=3).

2. Hour, T. C., Chen, L. and Lin, J. K. (1998) Comparative investigation on the mutagenicities of organophosphate, phthalimide, pyrethroid and carbamate insecticides by the Ames test and lactam tests. Mutagenesis 13, 157-166 (NSC-86-2621-B002-0082-Z) (SCI, CI=15).

3. Hour, T. C., Liang, Y. C., Chu I. S. and Lin J. K. (1999) Inhibition of eleven mutagens by various tea extracts, (-)epigallocatechin-3-gallate, gallic acid and caffeine. Food and Chemical Toxicology. 37(6) 569-79 (NSC-86-2621-B002-008-Z) (SCI, CI=31)

4. Hour, T. C., Lin-Siau, S. Y. and Lin, J. K. (1999) Suppression of N-methyl-N’-nitro-N-nitrosoguanidine- and S-nitrosoglutathione-induced apoptosis by Bcl-2 through inhibiting glutathione-S-transferase p in NIH3T3 cells. Toxicology Letter 110, 191-202 (NSC-87-2316-B002-011) (SCI, CI=13).

5. Hour, T. C., Chen, L. and Lin, J. K. (2000) Suppression of the activity of transcription of factor NF-kB by Bcl-2 protein in NIH3T3 cells: Implication of a novel NF-kB p50-Bcl-2 complex for the anti-apoptotic function of Bcl-2. European Journal of Cell Biology 79, 121-129 (NSC-87-2621- B002- 008-Z) (SCI, CI=13).

6. Hour, T. C., Chen, J, Huang, C. Y., Guan, C. Y., Lu, S. H., Hsieh, C. Y. and Pu, S.Y. (2000) Characterization of chemoresistance mechanisms in a series of cisplatin-resistant transitional carcinoma cell lines. Anticancer Res., 20, 3221-3226 (NSC89-2314-B-002-153) (SCI, CI=11).

7. Pu, Y. S., Cheng, J., Huang, C. Y., Guan, J. Y., Lu, S. H. and Hour, T. C.(2001) Cross resistance between and combined cytotoxic effects of paclitaxel and cisplatin in bladder cancer cells. J. Urology 165, 2082-2085 (NSC86-2314-B-002-118 )(SCI, CI=3).

8. Hour, T. C., Huang, C. Y., Guan, J. Y., Lu, S. H., Cheng, J. and Pu, Y. S. (2002) Curcumin enhances doxorubicin cytotoxicity in prostate cancer cells by suppression of NF-kB activation and induction of p21WAF1/CIP1 and C/EBPb expressions. Prostate. 15;51(3):211-8 (NSC 90–2314–B–002–213)(SCI, CI=12).

9. Pu Y. S., Hour, T. C., Chen, J, Huang, C. Y., Guan, J. Y. and Lu, S. H. (2002) Arsenic trioxide as a novel anticancer agent against human transitional carcinoma--characterizing its apoptotic pathway. Anticancer Drugs 13(3):293-300 (NSC 90-2314-B-002–572)(SCI, CI=18).

10. Pu, Y. S., Hour, T. C., Chen, J., Huang, C. Y., Guan, J. Y. and Lu, S. H. (2002) Cytotoxicity of arsenic trioxide to transitional carcinoma cells. Urology 60(2):346-350 (NSC 90-2314-B-002–572)(SCI, CI=3).

11. Pu Y. S., Hour, T. C., Chuang S. E., Cheng A. L., Lai M. K. and Kuo M. L. (2004) Interleukin-6 is responsible for drug resistance and anti-apoptotic effects in prostatic cancer cells. Prostate 60, 120-129 (NSC90-2314-B-002-213)(SCI, CI=5).

12. Hour, T. C., Huang, C. Y., Lin C. C., Cheng, J., Guan, J. Y., Lee, J. M. and Pu, Y. S. (2004) Characterization of molecular events in a series of bladder urothelial carcinoma cells with progressive resistance to arsenic trioxide. Anticancer Drugs 15, 779-785 (NSC92-3112-B-002-024) (SCI, CI=1).

13. Yang, S. H., Lu, M. C., Chien, C. M., Tsai, C. H., Lu, Y. J., Hour, T. C. and Lin, S. R. (2005) Induction of apoptosis in human leukemia K562 cells by cardiotoxin III. Life Science 76, 2513-2522 (NSC-2113-M-037-003) (SCI, CI=2).

14. Liao, Y. F., Hung, Y. C., Chang, W. H., Tsay, G. J., Hour, T. C., Hung, H. C., and Liu, G. Y. (2005) The PKC delta inhibitor, rottlerin, induces apoptosis of haematopoietic cell lines through mitochondrial membrane depolarization and caspases’ cascade. Life Science 77(6):707-719 (NSC 93-2320-B-040-048) (SCI, CI=1).

15. Huang, C. C., Hsu, P. C., Hung, Y. C., Liao, Y. F., Liu C. C., Hour, T. C., Kao, M. C., Tsay, G. J., Hung, H. C. and Liu, G. Y. (2005) Ornithine decarboxylase prevents methotrexate-induced apoptosis by reducing intracellular reactive oxygen species production. Apoptosis 10(4):895-907.

16. Ramanathan, B., Chen, C. H., Jan, K .Y., Hour, T. C., Yu, H. J., and Pu, Y. S. (2005) Resistance to paclitaxel is proportional to total cellular antioxidation capacity. Cancer Res 65(18):8455-8460. CI=1

17. Hsu, P. C., Hour, T. C., Liao, Y. F., Hung, Y. C., Liu, C. C., Chang, W. H., Kao, M. C., Tsay, G. J., Hung, H. C. and Liu, G. Y. (2006) Increasing Ornithine decarboxylase activity is another way of prolactin preventing methotrexate-induced apoptosis: crosstalk between ODC and BCL-2. Apoptosis 11(3):389-399.

18. Pu, Y. S., Hsieh, M. W., Wang, C. W., Chin, H. C., Huang, C. Y., Lin, C. C., Guan, J. Y., Lin, S. R. and Hour, T. C.* (2006) Epidermal growth factor Receptor inhibitor (PD168393) potentiates cytotoxic effects of paclitaxel against androgen-independent prostate cancer cells. Biochem Pharma 71(6):751-760.

19. Hour, T. C, Huang S. W., Lin, C. C., Huang, C. Y., Chen, Jun., Chiu, A. W., Chen, C. J. and Pu, Y. S. (2006) Differential expression of molecular markers in arsenic- and non-arsenic-related urothelial cancer. Anticancer Res 26(1A):375-378.

20. Huang, Y. T., Huang, Y. H., Hour, T. C., Pan, B. S., Liu, Y. C. and Pan, M. H. (2006) Apoptosis-inducing active components from Corbicula fluminea through activation of caspase-2 and production of reactive oxygen species in human leukemia HL-60 cells. Food Chem Toxicol 44(8):1261-1272.

21. Liu, G. Y., Liao, Y. F., Hsu, P. C., Chang, W. H., Hsieh, M. C., Lin, C. Y., Hour, T.C., Kao, M. C., Tsay, G. J. and Hung, H. C. (2006) Antizyme, a natural ornithine decarboxylase inhibitor, induces apoptosis of aematopoietic cells through mitochondrial membrane depolarization and caspases' cascade. Apoptosis 11(10):1773-1788.

22. Lin, C. C., Hsu, C. H., Hour, T. C., Cheng, A. L., Huang, C. Y., Huang, K. H., Chen, J. and Pu, Y. S. (2007) Weekly paclitaxel and high-dose 5-fluorouracil plus leucovorin in hormone-refractory prostate cancer: in vitro combined effects and a phase II trial. Uro Oncol-Semin 25: 207-213.

23. Liu, C. H., Huang, J. D., Huang, S. W., Hour, T. C., Huang, Y. K., Hsueh Y. M., Chiou, H. Y., Lee, T. C., Jan, K. Y., Chen, C. J. and Pu, Y. S. (2008) Androgen receptor gene polymorphism may affect the risk of urothelial carcinoma. J Biomed Sci 15(2):261-269.

24. Liao, Y. F., Hung, H. C., Hsu, P. C, Kao, M. C., Hour, T. C., Tsay, G. J. and Liu, G. Y. (2008) Ornithine decarboxylase interferes with macrophage-like differentiation and matrix metalloproteinase-9 expression by tumor necrosis factor alpha via NF-κB. Leukemia Research32(7):1124-40.

25. Liao, Y. F., Hung, H. C., Hour, T. C., Hsu, P. C., Kao, M. C., Tsay, G. J. and Liu G. Y. (2008) Curcumin induces apoptosis through ornithine decarboxylase-dependent pathway in human promyelocytic leukemia HL-60 cells. Life Science 82(7-8):367-375.

26. Pu, Y. S., Wang, C. W., Liu, G. Y., Kuo, Y. Z., Huang, C. Y., Kang, W. Y., Shun, C. T., Lin, C. C., Wu, W. J., and Hour, T. C.* (2008) Down-regulated Expression of RhoA in human conventional renal cell carcinoma. Anticancer Res 28:2039-2044.

27. Hour, T. C., Kuo, Y. Z., Liu, G. Y., Kang, W. I., Huang, C. Y., Tsai, Y. C, Wu, W. J., Huang, S. P. and Pu, Y. S. (2009) Down-regulation of ABCD1 in human renal cell carcinoma. Int J Biol Markers24 (3): 171-178

28. Pu, Y. S., Huang C. Y., Kuo, Y. Z., Kang, W. Y., Liu, G. Y., Huang, A. M., Yu, H. J., Lai, M. K, Huang, S. P., Wu, W. J., Chiou, S. J. and Hour, T. C.* (2009) Characterization of membranous and cytoplasmic EGFR expression in human normal renal cortex and renal cell carcinoma. Journal Biomed Science12;16(1):82-92.

29. Lin, K. W., Huang, A. M., Tu, H. Y., Weng J. R., Hour, T. C., Wei, B. L., Yang, S. C., Wang, J. P., Pu, Y. S. and Lin, C. N. (2009) Phloroglucinols Inhibit Chemical Mediators and Xanthine Oxidase, and Protect Cisplatin-Induced Cell Death by Reducing Reactive Oxygen Species in Normal Human Urothelial and Bladder Cancer Cells. J. Agric. Food Chem. 14;57(19):8782-8787.

30. Tu, H. Y., Huang, A. M., Wei, B. L., Gan, K. H., Hour, T. C., Yang, S. C., Pu, Y. S. and Lin, C. N. (2009) Ursolic acid derivatives induce cell cycle arrest and apoptosis in NTUB1 cells associated with reactive oxygen species. Bioorg. & Med. Chem. 15;17(20):7265-7274.

31. Chen, H. L., Lin, K. W., Huang, A. M., Tu, H. Y., Wei, B. L., Hour, T. C., Yen, M. H., Pu, Y. S. and Lin, C. N. (2010) Terpenoids induce cell cycle arrest and apoptosis from the stems of Celastrus kusanoi associated with reactive oxygen species. J Agric Food Chem. 58(6):3808-12.

32. Tu, H. Y., Huang, A. M., Hour, T. C., Yang, S. C., Pu, Y. S. and Lin, C. N. (2010) Synthesis and biological evaluation of 2',5'-dimethoxychalcone derivatives as microtubule-targeted anticancer agents. Bioorg Med Chem. 18(6):2089-98.

33. Ping, S. Y.,* Hour, T. C.,* Lin S. R. and Yu D. S. (2010) Taxol synergizes with antioxidants in inhibiting hormal refractory prostate cancer cell growth. Uro Oncol-Semin. 28:170-179 (*: co-first authors)

34. Hour, T. C., Lai, Y. L., Kuan, C. I., Chou, C. K., Wang, J. M., Tu, H. Y., Lin, C. S., Wu, W. J., Pu, Y. S., Sterneck, E. and Huang, A. M. (2010) CEBPD induces SOD1 expression and cisplatin resistance in human urothelial carcinoma cells. Biochem Pharma 80:325-334

35. Huang, C. Y., Chen, Jeff Y. F., Wu, J. E., Pu, Y. E., Liu, G. Y., Pan M. H., Huang Y. T., Huang, A. M., Hwang C. C., Chung S. J. and Hour T. C.* (2010) Ling-Zhi polysaccharides potentiates cytotoxic effects of anti-cancer drugs against drug-resistant urothelial carcinoma cells. J. Agric. Food Chem. 58: 8798-8805.

36. Chiu, C. C., Chen, B. H., Hour, T. C., Chiang, W. F., Wu, Y. J., Chen, C. Y., Chen, H. R., Chan, P. T., Liu, S. Y. and Chen, Jeff Y. F. (2010) Betel quid extract promotes oral cancer cell migration by activatinga muscarinic M4 receptor-mediated signaling cascade involving SFKs and ERK1/2. Biochem. Biophys. Res. Commun. 13;399(1):60-65.

37.Lin CN, Huang AM, Lin KW, Hour, T. C., Ko HH, Yang SC, Pu YS. (2010) Xanthine oxidase inhibitory terpenoids of Amentotaxus formosana protect cisplatin-induced cell death by reducing reactive oxygen species (ROS) in normal human urothelial and bladder cancer cells. Phytochemistry 71(17-18):2140-6.

38.Lin, K. W., Huang, A. M., Tu, H.Y., Lee, L. Y., Wu, C.C., Hour, T. C., Yang, S. C., Pu, Y.S. and Lin CN.(2010) Xanthine oxidase inhibitory triterpenoid and phloroglucinol from guttiferaceous plants inhibit growth and induced apoptosis in human NTUB1 cells through a ROS-dependent mechanism. J. Agric. Food Chem. (in press)

*CI= cited index; 論文被引用次數